Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression
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چکیده
منابع مشابه
Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression.
Negative affect is critical for conferring vulnerability to opiate addiction as reflected by the high comorbidity of opiate abuse with major depressive disorder (MDD). Rodent models implicate amygdala prodynorphin (Pdyn) as a mediator of negative affect; however, evidence of PDYN involvement in human negative affect is limited. Here, we found reduced PDYN mRNA expression in the postmortem human...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2013
ISSN: 0021-9738
DOI: 10.1172/jci70395